Family: Sir Ephraim McDowell / Margaret Irvine (McDowell) (F683)
m. 1721Robert Irvine (1655-1729) 
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Margaret Wylie (Irvine) (1658-1724)
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| Thomas Irvine (1676- ) |
Mary Irvine (McDowell) (1684-1782)  |
| Alexander Irvine (1685- ) |
| George Irvine (1687- ) |
| David Irvine (1689- ) |
| William Irvine (1691-1767) |
| Rev. Robert Irvine (1698-1788) |
| John Robert Irvine (1700-1788) |
| James Irvine (1705-1778) |
| Samuel Irvine (1710-1783) |
| Sir Ephraim McDowell (1673-1774) |
| Margaret Irvine (McDowell) (1674-1728)
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| Mary Elizabeth McDowell (Greenlee) (1707-1809) |
| Capt John McDowell (1714-1742) |